The paper considers the problem of meeting ergonomic requirements to the on-board equipment layout in compartments of the manned spacecraft and space stations. It describes features of the operator interaction processes with the equipment during their ground and flight (or intended) operation including diagnosis of the on-board systems, which affects the approach to assessing the energy costs. Methodological assumptions are provided, they relate to accounting for the environmental factors of the operator’s workspace. Additions are proposed to develop fundamentals of the methodology for preliminary ergonomic optimization of the equipment arrangement in terms of assessing the operator’s energy costs under zero-gravity and testing the permissible load conditions. Besides, recommendations are given to overcome the algorithmic collision associated with massive large-sized units of the on-board equipment. Moreover, the methodology was validated using the example of a pressurized compartment of one of the manned spacecraft, and its development and verification procedure was described.

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