Analysis of advanced projects of space exploration shows that the main developmental trend in the global space activity should include a significant expansion of spacecraft groups of different types and purposes, the complication of missions, focus on the deep space research. It predetermines the necessity of solving qualitatively new tasks primarily related to the establishment of efficient space infrastructure. The article discusses new methodological approaches to the research of particular aspects of the large-scale spacecraft constellation control problems. In particular, there is a description of approaches to optimization of allocation of ground facilities for spacecraft control, to optimization of control complex structures, to the development of rational model for the flight information operative control.